AMAN DEEP, MANİSH KUMAR, RAKESH PAHWA, SUMEET GUPTA, SHAİLENDRA BHATT, BEENA KUMARİ, PRABHAT KUMAR UPADHYAY, A PANDURANGAN
Acta Pharmaceutica Sciencia - 2021;59(1):559-580
The main objective of the present study was to developed and evaluated the Bifonazole (BFZ) loaded Nanostructured lipid carriers (NLCs) for topical delivery of BFZ. BFZ-NLCs were deve560ted for Particle size, EE, DL and drug release profiles. The invitro release studies show better drug release over 24h as compared to the marketed formulation. Ex-vivo skin permeation and Pharmacodynamic studies indicated that NLCs get effectively reduced the fungal infection. In-vitro antifungal activity study shows that the BFZ-NLCs were more effective in inhibiting the growth of Candida Albicans. Therefore, the study concludes that NLCs showed a continuous release profile and has the prospective for treatment of topical fungal infections.
