AJİNATH SHİRSAT, SANJEEVANİ DESHKAR, SATİSH SHİROLKAR, VAİBHAV GATADE, ARPANA BHALERAO
Acta Pharmaceutica Sciencia - 2011;53(2):269-281
A microparticulate system consisting of guar gum core coated with pH dependent polymer (HPMC AS MF) to deliver Budesonide specifically to terminal ileum and proximal colon has been reported. These microspheres are proposed to deliver the drug to ileo-cecal junction and proximal region of colon. Both guar gum microspheres and HPMC AS microspheres were prepared using Emulsion-solvent evaporation technique. Effect of formulation variables for double microencapsulation like coat: core ratio (4:1, 5:1, 6:1) and span 80 concentrations (2%, 3%, 4%) was studied using 32 factorial design. The obtained microspheres analyzed for particle size of microspheres, % encapsulation efficiency, % drug release after 2 h and % drug release after 5 h. In-vitro dissolution study of optimized formulations in presence of rat cecal content was carried out. The results of analysis of variance test for responses measured indicated that the test is significant.
