Mehmet Akif DURMUŞ, Selda KÖMEÇ
İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi - 2026;14(1):219-227
This study aimed to evaluate the antibiotic susceptibility profiles and resistance trends of these bacteria isolated from blood cultures at our hospital between 2021 and 2024. Bacterial identification and antibiotic susceptibility testing were performed using MALDI-TOF MS and the Phoenix M50 system, respectively. A total of 1,054 Staphylococcus aureus isolates were evaluated, including 384 MRSA and 670 MSSA. Additionally, 914 isolates of Enterococcus faecalis and 692 isolates of Enterococcus faecium were assessed. The S. aureus isolates demonstrated 98-100% susceptibility to vancomycin, teicoplanin, and linezolid. However, susceptibility to ciprofloxacin significantly decreased: MRSA susceptibility decreased from 81% to 61% (p = 0.002), and MSSA susceptibility decreased from 94% to 74% (p < 0.001). For E. faecalis, susceptibility to streptomycin decreased from 63% to 52% (p = 0.018). Conversely, in E. faecium, susceptibility to linezolid increased from 88% to 95% (p = 0.029). The MRSA rate was 36.4%, and susceptibility to vancomycin and linezolid remained high, at 98-100%. The increase in ciprofloxacin resistance is noteworthy. For both susceptibility of E. faecalis and E. faecium to linezolid, teicoplanin, and vancomycin was above 90%. These findings highlight the importance of infection control and the rational use of antibiotics.
