ŞENGÜL ÇAĞLAYAN, SÜMEYRA BAŞARAN ÇOBAN, KADİR ULU, BETÜL SÖZERİ
Comprehensive Medicine - 2025;17(1):13-21
Objective: This study aimed to evaluate the clinical and laboratory characteristics of gastrointestinal (GI) involvement in pediatric IgA vasculitis (IgAV) patients, with a particular focus on identifying risk factors for severe complications and exploring current management strategies. Materials and Methods: This retrospective cohort study included pediatric patients diagnosed with IgAV who were followed at a tertiary medical center between January 2019 and March 2024. Patients were divided into two groupssevere and non-severe GI involvementand data were analyzed comparatively. Results: A total of 265 patients were included in the study, of whom 109 (41.1%) had GI involvement. Among these, 35 (32.1%) were classified as having severe GI involvement, while 74 (67.9%) were categorized as having non-severe involvement. All patients with GI symptoms reported abdominal pain, with 37 (33.9%) experiencing nausea and vomiting. Positive fecal occult blood tests were observed in 59 (54.1%) patients, melena in 4 (3.6%), and hematochezia in 14 (12.8%). Radiological findings showed intestinal wall edema in 28 (25.6%) patients, intussusception in 7 (6.4%), and intestinal perforation in 1 patient (0.9%). Laboratory markers such as NLR, MLR, SII, SIRI, SIAI, and CRP/albumin ratios were significantly elevated in the severe GI involvement group (p< 0.05), while albumin levels were significantly lower (p< 0.001). Conclusion: NLR, MLR, SII, SIRI, SIAI, and CRP/albumin ratios were found to predict severe GI involvement, demonstrating their potential as useful clinical tools for early identification of high-risk patients.
