Abdulrahman Naser, Mustafa Dinç, Merve Demireller
Endocrinology Research and Practice - 2026;30(1):30-36
Objective: Cardiometabolic risk factors and biomarkers reflecting various pathophysiological path- ways differ between men and women. In this study, gender differences were analyzed in some car - diometabolic risk indices and evaluated the indicators of arterial stiffness (AS) in men compared to women with prediabetes (preD) without cardiovascular disease. Methods: Data from 581 individuals (189 with normal plasma glucose and 392 with preD, aged 18-86 years) were analyzed cross-sectionally. The relationship between gender and different biomarkers was evaluated. Aortic stiffness index (ASI) was used to represent AS and was calculated as follows: ln [systolic blood pressure (SBP)/ diastolic blood pressure]/ [(ascending aorta systolic diameter - ascending aorta diastolic diameter (ADS)]/ADS. Multivariable linear regression was used to explore indicators of ASI. Results: Women with preD were older than men. The frequencies of comorbidities were significantly higher in preD men. Epicardial adipose tissue (EAT) (4.27 +/- 1.87 vs. 3.77 +/- 1.94), ASI (15.78 +/- 11.34 vs. 12.22 +/- 13.04), and lipid accumulation product index (LAPI) [59.98 (51.68) vs. 54.36 (57.04)] were significantly higher in preD men than in preD women. There was a significant correlation between ASI and age, body mass index (BMI), metabolic syndrome, waist circumference (WC), EAT, LAPI, fast- ing plasma glucose (FPG), hemoglobin A1c (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR), insulin, creatinine, glomerular filtration rate (GFR), and SBP . In men, ASI was significantly correlated with age, MetS, BMI, WC, EAT, FPG, HOMA-IR, HbA1c, GFR, red blood cell dis- tribution width, and SBP . Conclusion: These findings highlight that the development of AS in preD may be due to common and sex-specific risk factors.
