FİROOZEH REZAEİ, NEDA ZAREEİ, NEMATOLLAH RAZMİ, SAMAN NİKEGHBALİAN, NEGAR AZARPİRA
Experimental and Clinical Transplantation - 2021;19(2):154-159
Objectives: Human leukocyte antigen-G is an immuno - modulatory factor that affects acute allograft rejection and autoimmune diseases such as type 1 diabetes mellitus. In this study, possible associations between human leukocyte antigen-G 14-bp insertion/deletion polymorphism and acute pancreas rejection were investigated. Materials and Methods: Human leukocyte antigen-G genotyping was assessed in 102 Iranian pancreas transplant recipients (including 41 with acute rejection and 61 with nonacute rejection). Results were compared with 100 individuals in a normal control group. Results: No significant differences in genotype frequencies of human leukocyte antigen-G 14-bp insertion/deletion were observed in recipients who had acute rejection episodes. On the other hand, the insertion/insertion genotype was a risk factor for susceptibility to type 1 diabetes mellitus (odds ratio = 3.82, 95% confidence interval, 1.37- 11.22; P = .005). Conclusions: Our results provided evidence revealing that the human leukocyte antigen-G insertion/insertion genotype might be involved in the pathogenesis of type 1 diabetes mellitus.
