BETÜL AKÇEŞME, ABAS SEZER
International Journal of Medical Biochemistry - 2025;8(3):165-177
Objectives: Despite the advances and huge efforts in determination of efficient therapy options for diffuse large B cell lymphoma (DLCBL), various issues, including resistance and toxicity, are among the main concerns. Additional contributor to the poor prognosis is genomic complexity of DLBCL, where high number of mutations are associated with the DLBCL pathogenesis. Epigenetic regulations expand the complexity of gene expression process by various mechanisms, including histone deacetylation and DNA methylation, without altering the DNA sequence.
