GONADOBLASTOMA WITH DYSGERMINOMA IN A VIRILIZED ADOLESCENT WITH KARYOTYPE 46,XX: A CASE REPORT AND REVIEW OF THE LITERATURE

Tugce KANDEMIR, Esin Karakilic OZTURAN, Ozlem DURAL, Ayca Dilruba ASLANGER, Elif Inan BALCI, Aysel BAYRAM, Semen ONDER, Asli Derya KARDELEN, Melek YILDIZ, Sukran POYRAZOGLU, Firdevs BAS, Feyza DARENDELILER

Journal of Clinical Research in Pediatric Endocrinology - 2026;18(Suppl 1):37-44

İstanbul University, İstanbul Faculty of Medicine, Department of Pediatric Endocrinology, İstanbul, Türkiye

 

Gonadoblastoma is a rare gonadal tumor composed of sex cord cells and primitive germ cells. While the majority of gonadoblastomas are found in individuals with 46,XY gonadal dysgenesis, they are also rarely seen in patients with a 46,XX karyotype. We report a case of a 14.5 year-old girl presenting with an uncommon cause of virilization; a virilizing ovarian tumor. The patient underwent bilateral salpingo-oophorectomy. Upon histopathological examination, the excised tumor was confirmed to be bilateral gonadoblastoma, with dysgerminoma on the left side.