Ali Rıza GÜVERCİN, Mehmet AKTOKLU, Mehmet Orbay BIYIK, Mehmet Ali DEMİRCİ
Annals of Clinical and Analytical Medicine - 2026;17(4):299-304
Aim: This study aimed to evaluate whether readily available haemogram parameters and their ratios can predict the grade and prognosis of glial brain tumors. Methods: In this retrospective study, preoperative haemogram data of patients who underwent intracranial tumor surgery between 2007 and 2020 were analyzed. Blood samples collected within one week prior to surgery were evaluated. Statistical analyses were performed using SPSS 24. Normally distributed variables were analyzed with ANOVA, and non-normal variables with Kruskal-Wallis tests. Age was included as a covariate using ANCOVA due to its correlation with haemogram parameters. Categorical variables were analyzed using the chi-square test. Results: A total of 462 patients were included. Lower hemoglobin levels and higher lymphocyte counts were associated with grade I tumors, whereas higher neutrophil counts and neutrophil-to-lymphocyte ratio (NLR) were associated with grade IV tumors. After adjustment for age, platelet count was significantly higher in grade IV compared to grade III. Lymphocyte levels remained significantly higher in grade I compared to other groups. Platelet-to-lymphocyte ratio (PLR), initially non-significant, showed significant differences between grade I, II, and IV after age adjustment. Conclusion: Haemogram parameters may provide useful supplementary information in predicting tumor grade in glial brain tumors. These findings suggest that inexpensive and easily accessible blood markers could contribute to preoperative assessment and clinical decision-making. Larger, multicenter studies are needed to validate these results.
