WİLSON Y K CHAN, W L YEUNG, WONG S N SHELİA, WİNNİE W Y TSO, CLAUDİA CHEUNG, ELAİNE Y L KAN, PAMELA P W LEE, DANİEL K L CHEUK, SHAU YİN HA, WİNG LEUNG
Experimental and Clinical Transplantation - 2023;21(3):279-285
Hematopoietic stem cell transplant is potentially curative for relapsed/refractory leukemia. However, neurotoxicity is common and has been reported in 11% to 59% of children following hematopoietic stem cell transplant. Most pediatric studies of the neurological effects of hematopoietic stem cell transplant have focused on acute neurotoxicity. Limited information is available for long-term neurotoxicity, particularly those cases that are severe and permanent and caused by conditioning chemotherapy. Here, we report 2 cases of relapsed acute lymphoblastic leukemia that achieved long-term remission by haploidentical hematopoietic stem cell transplant but remained complicated with severe and persistent fludarabine-induced neurotoxicity.
