Mehmet Nuri YAKAR, Feyzullah Orkut DURAN, Batuhan BOSTAN, Özlem ACICBE, Olcay DİLKEN, Buğra KARAKAŞ, Ceren YİĞİT, Oğuzhan ALTIPARMAK, Mustafa ALTINAY
Türk Yoğun Bakım Dergisi - 2026;24(3):226-234
Methanol, a toxic substance, has been identified as a causative agent for lethal poisoning. The present case series includes nine patients admitted to the intensive care unit (ICU) due to methanol poisoning between 25th November 2024 and 13th January 2025. The median age of the patients was 49 (43-54) years, with eight of them being male. All patients exhibited high anion gap metabolic acidosis and underwent renal replacement therapy. The majority of the patients received a combination of ethanol and folinic acid therapies. It is noteworthy that a third of patients experienced a cardiopulmonary arrest either in their own homes or in the immediate period following their admission to the hospital. Six patients survived to ICU discharge: four were transferred to hospital wards or discharged from the hospital, and two were transferred to palliative care units. One patient died shortly after ICU admission, another died during prolonged ICU follow-up, and one was diagnosed with brain death and subsequently underwent organ procurement surgery. In conclusion, a deteriorated neurological state, receipt of cardiopulmonary resuscitation, and the presence of pathological findings in radiological imaging of the central nervous system, cardiac injury, vasopressor requirement, sepsis, and ventilator-associated pneumonia were likely to be associated with an increased risk of poor outcomes.
