SEDA DUMAN ÖZTÜRK, GUPSE TURAN, SEVGİYE KAÇAR ÖZKARA
Turkish Journal of Oncology - 2022;37(1):51-59
OBJECTIVE It was aimed to reevaluate uterine sarcoma cases diagnosed in our institution within the last 20 years according to current information and to provide intra-departmental standardization in the differential diagnosis and reporting. METHODS Totally 84 uterine sarcoma cases were re-examined. Recurrence, metastasis, and prognostic data were collected from the patient files. Immunohistochemistry panel consisting of CD10, h-caldesmon, and cyclin D1 was applied to the representative tumor tissues. The relationships between the parameters studied were evaluated statistically. RESULTS Statistically significant differences were found between different histopathological types of uterine sarcomas (US) in terms of age distribution, tumor diameter, mitotic index, necrosis, depth of myometrial invasion, cervical, adnexial and/or omental involvement, lymphovascular invasion, lymph node metastasis, recurrence, and distant metastasis. Statistically significant correlation was determined between the prognosis of the patients and mitotic activity of their tumors and the presence of distant metastasis. The immunohistochemistry panel was found to have significant contribution to the histomorphological examination in the differential diagnosis. CONCLUSION Routine use of CD10, h-caldesmon, and cyclin D1 in the histopathological evaluation of US and establishing an updated standard checklist was thought to be beneficial for the differential diagnosis and reporting prognostic parameters.
