Zahraa A. Rzaij, Nuha Jabbar Alrikaby
Perinatal Journal - 2026;34(1):74-80
The opportunistic intercellular blood parasite Toxoplasma gondii can occur a dangerous coinfection for pregnant women have general chronic systemic lupus erythematosus ( GCSLE) may causes abortions or life threatening for both mother and fetus. 153patients women divided into: G?(seropositive toxoplasmosis)/56, G beta (GCSLE seropositive toxoplasmosis)/43, and G ?(GCSLE seronegative toxoplasmosis)/44, also 45 healthy women as control G ?, the average ages +/-S.d was 31.34+/-3. 25(22 -45) years . The abortion status for all samples had studied. Both Anti -Toxo antibodies ( IgM and IgG) detected via ELISA, and Antibeta2 -Glycoprotien I(antibeta2GpI) IgM and IgG antibodies measured by full automated Alegria(R) device, all titer values compared with standard cut off for each indicator. Obviously the results of this treatise manifested there was a significant elevation in means values of the blood indicators (ESR and C -RP)and serum immunological antibodies anti -Toxo(IgM and IgG), and anti -GPI (IgM and IgG)were (35.5mm/hr. and 19.2mg/dl) and (1.86 and 9.93)Index, and (10.57and 14.75)U/ml respectively in the group of GCSLE women infected with toxoplasmosis(Gbeta) compared to all means values in the rest subjected groups statistically both p<0.01 and ?(Scheffe)=0.01, in addition the highest percentage in number of recurrent abortion was in Gbeta 21/44(47.72%) at p<0.05. The present study concluded that toxoplasmosis infection in women with GCSLE is a risk factor one through the progression of syndrome severity with accompany mischievous health effects, the other is the increasing in recurrent abortions occurrence probability, due to the activation of the parasite's dormant phases causes the elevation of antibodies and autoantibodies, because the strong synergistic correlation between them during pregnant stages.
