Murat Gök, Furkan Karahan, Umutcan Vurucu, Alparslan Kurtul, Kenan Yalta
Interventional Cardiology Perspectives - 2025;1(3):98-103
Background: Eosinophils, a type of inflammatory cell, have been implicated in thrombosis and proposed as a prognostic marker for various atherosclerotic cardiovascular diseases. Aim: This study determine the value of an eosinophil count (EOSC) in predicting short-term prognosis in patients with acute pulmonary embolism (APE). Study Design: Retrospective cohort study. Methods: In this study, a total of 453 patients who were admitted with APE from September 2015 to July 2020 were retrospectively examined, and their admission complete blood cell counts were measured. The optimal cut-off point for EOSC was determined using receiver operating characteristic analysis. Patients were classified into the low EOSC (<=0.45) and high EOSC (>0.45) groups. Multivariate logistic regression analysis was performed to investigate the independent association between EOSC and early mortality (in-hospital and 30-day) outcomes in patients with APE. Results: Throughout the hospitalization and 30-day follow-up, a total of 33 deaths (7.3%) occurred. Of the patients who survived, those who died were older and had significantly lower EOSC (p<0.001) but significantly higher white blood cell (WBC) (p<0.001) and platelet (p=0.025) counts. Multivariate regression analyses identified that decreased EOSC (<=0.45) [odds ratio (OR): 4.518; p=0.003], increased WBC count (OR: 1.135; p=0.012), and older age (OR: 1.048; p=0.029) were independently associated with short-term mortality. Conclusion: A significant correlation was observed between low EOSC and elevated short-term mortality in patients with APE. Thus, blood EOSC can be used in daily clinical practice as a novel marker that correlates with the risk stratification of patients with APE.
