OSMAN MAVİŞ, SILA ÖKSÜZ, BANU BOYUK, UMİT BULUT, OGUZHAN ZENGİ, KORHAN KAPUCU
Southern Clinics of Istanbul Eurasia - 2023;34(1):36-41
INTRODUCTION: Volume excess is frequently observed in chronic kidney disease (CKD) patients and over time may induce diastolic dysfunction and its continuation of cardiac failure. It was aimed to identify the correlation between E/e’ ratio, entering use in recent times and asso-ciated with left ventricle filling pressure, and NT-proB-type natriuretic peptide (proBNP), a substantial indicator in heart failure. METHODS: The study included 44 euvolemic CKD patients with preserved left ventricular ejection fraction and without cardiovascular disease (25 women, 19 men) and 26 healthy controls (15 women, 11 men). NT-proBNP levels were measured with the ELISA method and all participants were assessed with transthoracic conventional Doppler and tissue Dop-pler echocardiography to examine the relationship between NT-proBNP values with E/e’ ra-tio which is the peak early diastolic mitral rate to peak early diastolic mitral annular velocity. Results: The patient group comprised 25 women (56.8%) and 19 men (43.2%) and the mean age was 59.36±9.26 years. Healthy controls comprised 15 women (57.7%) and 11 men (4.23%) with mean age of 56.58±10.39 years. NT-proBNP measurements and E/e’ ratios were concluded to be higher in the patient group compared to the control group (p<0.001). Taking cutoff value of 300 pg/mL for NT-proBNP as the basis, the sensitivity was 53.66% and specificity was 100%. With E/e’ cut-off value of 15, the sensitivity was 86.36% and specificity was identified as 73.08%. DISCUSSION AND CONCLUSION: In our study, NT-proBNP and E/e’ values were identified to be important pa-rameters for the prediction of diastolic dysfunction in chronic renal failure patients without clinical findings of heart failure. Larger, extensive, comprehensive, and prospective studies investigating this issue are necessary to confirm the value and usefulness of both NT-proBNP and the E/e’ ratio in clinical practice.
