NEWMAN OSAFO, ODURO KOFİ YEBOAH
Acta Pharmaceutica Sciencia - 2022;60(1):85-99
Xylopia aethiopica is traditionally employed, as fruit decoction, in the management of bronchitis, asthma and arthritis in Ghana. This study is to evaluate the involvement of the hydro-ethanol extract of the dried fruit of X. aethiopica on some inflammation pathways by employing in vivo murine models. X. aethiopica (30, 100, 300 mg kg-1) suppressed the mean maximal swelling attained at 60-90 min and also decreased the total paw swelling induced over 2.5-3 h significantly (p < 0.05). The extract suppressed mean maximal swelling attained at 60-90 min in the respective histamine, serotonin, bradykinin and prostaglandin E2-induced oedema models when compared with their respective mean inflamed control responses. Total paw swellings induced over the 2.5-3 h were also significantly suppressed in all mediator-challenged mice. The current study establishes that X. aethiopica extract has inhibitory effect on histamine, serotonin, bradykinin and prostaglandin E2 in acute inflammation.
