Turan Eray SEVEN, Hüseyin Hakan AMİOĞLU, Gökhan KARACA
Journal of Comprehensive Surgery - 2026;4(1):1-4
Aims: Appendectomy is one of the most commonly performed surgical procedures for acute abdominal pain. Although inflammatory changes are the predominant pathological findings, unexpected neoplastic lesions may also be identified in a small proportion of appendectomy specimens. Methods: This study included all patients who underwent appendectomy at our institution between August 2022 and August 2025. All appendix specimens removed, regardless of the surgical indication, were evaluated. Pathology reports were retrieved from the electronic archive and analyzed on a patient-specific basis. Results: A total of 1168 appendectomy cases were included. Patient ages ranged from 7 to 84 years, with a median age of 33 years (IQR: 24-42) and a mean age of 34.6+/-12.5 years. Of the patients, 690 (59.1%) were male and 477 (40.8%) were female; sex information was unavailable for one patient. Malignancy was detected in three cases. According to morphology codes, malignancy subtypes were recorded as NET G1 (8240/3) and unspecified malignant neoplasm (8000/3). In addition, four cases were diagnosed as low-grade appendiceal mucinous neoplasm (LAMN). The ages of patients with LAMN ranged from 35 to 65 years, with an equal sex distribution. Conclusion: This study demonstrates that the incidence of malignancy in appendectomy specimens is low; however, distinct histopathological entities with potential implications for clinical management may be encountered. In addition to malignant subtypes such as neuroendocrine tumors and adenocarcinoma, LAMN should be carefully reported as a separate diagnostic category. Given the potential association of LAMN with complications such as pseudomyxoma peritonei, these lesions carry particular clinical relevance. The findings underscore the importance of thorough histopathological evaluation of all appendectomy specimens and suggest that reporting contemporary incidence data from our country may contribute to the standardization of pathological reporting and postoperative follow-up strategies.
