Mehlika ISCAN, Omer YAVUZ, Ali YEGINSU
Current Thoracic Surgery - 2026;11(1):52-61
Background: Blood-based inflammatory and nutritional biomarkers are increasingly used in non-small cell lung cancer (NSCLC), but their early postoperative behavior after uniportal minimally invasive anatomical lung resection remains unclear. This study evaluated perioperative changes in selected indices between the preoperative period and the standardized early postoperative outpatient assessment. Materials and Methods: This retrospective observational study included 48 consecutive patients with histopathologically confirmed NSCLC who underwent uniportal minimally invasive anatomical lung resection between January 2024 and December 2025. Patients who underwent completion resection, had non-NSCLC histology, or lacked paired laboratory data were excluded. Preoperative laboratory values were compared with those obtained at the postoperative outpatient assessment between postoperative days 25 and 34. The primary endpoint was the change in hemoglobin, albumin, lymphocyte, and platelet score (HALP). Secondary endpoints were changes in neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, prognostic nutritional index, C-reactive protein-to-albumin ratio, and systemic immune-inflammation index. Results: The cohort included 37 uniportal video-assisted thoracic surgery and 11 uniportal robotic-assisted thoracic surgery patients. HALP decreased significantly, whereas platelet-to-lymphocyte ratio and C-reactive protein-to-albumin ratio increased significantly. Hemoglobin and hematocrit decreased, while platelet count and C-reactive protein increased. No significant changes were observed in neutrophil-to-lymphocyte ratio, prognostic nutritional index, systemic immune-inflammation index, white blood cell count, neutrophil count, lymphocyte count, creatinine, or albumin. Conclusions: The standardized postoperative outpatient assessment after uniportal minimally invasive anatomical lung resection for NSCLC suggested a selective biomarker pattern that may reflect a non-uniform early postoperative recovery process after uniportal anatomical lung resection.
