Özge KÖPRÜLÜ, Nazlı POLAT, Gözde AKIN KAĞIZMANLI, İbrahim Mert ERBAŞ, Özlem NALBANTOĞLU, Hüseyin Anıl KORKMAZ, Behzat ÖZKAN
The Journal of Pediatric Research - 2026;13(1):65-71
Aim: Polycystic ovary syndrome (PCOS) is increasingly recognized as a systemic disorder associated with metabolic abnormalities and chronic inflammation. In this study, we aimed to investigate the relationship between androgen levels and inflammatory markers in adolescents with PCOS. Materials and Methods: Eighty-nine patients with PCOS were analyzed retrospectively. Inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), were assessed. Androgen levels and metabolic parameters were also evaluated. Results: The inflammatory markers were not significantly associated with androgen levels or hyperandrogenism. No significant differences in NLR, PLR, or SII were observed between adolescents with and those without hyperandrogenism or between patients with obesity and those without obesity (all p>0.05). Body mass index (BMI) and BMI-standard deviation scores were not correlated with inflammatory markers. In contrast, homeostasis model assessment of insulin resistance showed a weak but statistically significant positive correlation with SII. Conclusion: Our findings demonstrate that inflammatory markers, including NLR, PLR, and SII, were not significantly associated with androgen levels. Furthermore, these markers did not differ according to the presence of obesity or hyperandrogenism.
