NASİR IDKAİDEK, ESRAA IDKAİDEK
Journal of Research in Pharmacy - 2025;29(4):1374-1378
The aim of this commentary is to investigate the interplay of Extended Clearance Classification System (ECCS) and Salivary Excretion Classification System (SECS). ECCS utilized the involvement of transporters to classify drugs based on permeability, ionization and molecular weight for the purpose of predicting rate determining clearance. On the other hand, SECS classified drugs based on permeability and protein binding for the purpose of predicting salivary excretion of drugs. Conclusion: The proposed Salivary Excretion Classification System (SECS) can be used as a guide for drug salivary excretion based on permeability and protein binding, but not transporters involved.
