Mehtap SOLMAZ, Yelda DAĞCIOĞLU, Umut Safiye ŞAY COŞKUN
Kocaeli Üniversitesi Sağlık Bilimleri Dergisi - 2026;12(1):8-15
Objective: The aim of the study is to guide clinicians regarding empirical treatment in our region and to contribute to the literature by determining antibiotic resistance frequency of E. coli and Klebsiella pneumoniae strains which cause urinary tract infections (UTIs). Methods: In the study, a total of 27,443 mandatory cultures sent from various outpatient clinics and services between January 2016 and September 2019 were retrospectively evaluated. Bacterial identification and antibiotic susceptibilities were performed by conventional methods and automatic systems. SPSS 25 statistical package program was used in the evaluation of the study data, and the statistical significance level of the results was accepted as p<0.05. Results: A total of 333 Escherichia coli and 373 Klebsiella pneumoniae isolates from which growth was detected in urine samples were included in the study. The antibiotic to which E. coli isolates were most resistant was ampicillin (48.4%), and no antibiotic resistance was detected against fosfomycin and was statistically significant. The least resistant antibiotic of Klebsiella pneumoniae strains was amikacin (4.27%), and the most resistant antibiotic was ceftazidime (58.73%). Renal failure was the most common comorbidity. Conclusion: Increasing antibiotic resistance makes the treatment of UTIs more difficult. It is thought that the study data will guide clinicians in contributing to the success of treatment by selecting the appropriate antibiotic and in preventing unnecessary or incorrect antibiotic use. Fosfomycin is an important agent in the empirical treatment of ESBL positive E. coli and amikacin in K. pneumoniae isolates.
