Aysegul OGLAKCI ILHAN, Almila SENAT, Osman ERINC, Soner YESILYURT
Medical Science and Discovery - 2026;13(4):64-70
Objective: This study is a retrospective investigation of the relationship among vitamin D levels, neutrophil-to-lymphocyte ratio (NLR), and routine inflammatory markers. Material and Methods: A total of 3,859 individuals were included in this retrospective cross-sectional study. Participants were evaluated for age, sex, vitamin D level, C-reactive protein (CRP), erythrocyte sedimentation rate, lymphocyte, neutrophil, white blood cell (WBC), ferritin, and alanine aminotransferase (ALT) levels. Vitamin D levels were categorized as >30 ng/mL (normal), 20-30 ng/mL (insufficient), <20 ng/mL (deficient), and <10 ng/mL (severe deficiency). Differences and correlations between the groups were analyzed using SPSS v26 software. Results: The participants' average age was 46.9+/-16.0 years, and 73.1% of them were female. The average vitamin D level was 19.7+/-12.0 ng/mL. CRP and WBC levels were significantly higher in the severe deficiency group (p<0.01). Vitamin D levels showed a negative correlation with CRP (r = -0.52, p = 0.002) and WBC (r = -0.079, p = 0.000). A borderline negative correlation was observed between vitamin D and NLR (r = -0.32, p = 0.051). Ferritin, eGFR, and hemoglobin levels also showed significant differences across vitamin D categories. Inflammatory markers were higher in men, whereas vitamin D levels were significantly lower in women. Conclusion: Vitamin D deficiency is associated with elevated inflammatory markers. These findings indicate that vitamin D levels should be considered in the clinical evaluation of systemic inflammation and related health conditions.
