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ADR Yönetimi

INVESTIGATION OF THE PATTERN OF CHANGES IN HEPATIC ARTERY RESISTIVE IN PATIENTS UNDERGOING DECEASED DONOR LIVER TRANSPLANTATION

Mohsen ALIAKBARIAN, Fahimeh HOSEINZADEH, Maryam SALARI, Rozita KHODASHAHI, Amir Mahmoud AHMADZADEH

Experimental and Clinical Transplantation - 2026;24(2):158-164

Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad

 

Objectives: Postoperative hepatic artery resistive index is strongly influenced by perioperative hemodynamics and graft-related factors. However, evidence linking prognostic variables to early postoperative hepatic artery resistive index remains limited and heterogeneous. This study explored changes in hepatic artery resistive index and whether changes were associated with patient-level exposures and prognostic variables. Materials and Methods: We analyzed retrospective data from 323 patients who underwent deceased donor liver transplant at the Montaserieh Transplant Center Registry of Mashhad University of Medical Sciences between 2014 and 2021. Results: Mean age of patients was 48.71 +/- 1.022 years. Mean hepatic artery resistive index increased among patients aged <=50 years from day 0 (0.762 +/- 0.149) to day 1 (0.789 +/- 0.141), showed continuous upward trend in patients aged >50 years, increasing from day 0 (0.778 +/- 0.136) to day 3 (0.835 +/- 0.105), and was significantly higher in patients aged >50 years on day 2 (0.031; P = .012) and day 3 (0.044; P < .001) compared with patients aged <=50 years. Conclusions: With an association shown between age and higher hepatic artery resistive index, trend analysis may help identify high-risk groups for arterial thrombosis.