Şeyda Gül ÖZCAN, Narmin MAMMADHASANOVA, Mevlüt Tamer DİNÇER, Zeynep ATLI, Nurhan SEYAHİ, Sinan TRABULUS
Cerrahpaşa Medical Journal - 2026;50(1):1-6
Objective: This study aimed to investigate the relationship between the uric acid-to-high-density lipoprotein cholesterol ratio (UHR) and the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) with the progression of chronic kidney disease (CKD). Methods: This research was designed as a retrospective type 2 cohort study. The study evaluated the outpatient clinic records and hospital automation system data of patients who first presented to the nephrology outpatient clinic between January 2015 and December 2016, with a 5-year follow-up. Patients aged 18 years and over, diagnosed with CKD, and under regular outpatient follow-up were included. Patients with active infections, hematological diseases, inflammatory diseases, or malignancies were excluded. The UHR and MHR ratios of CKD patients were measured in the first, third, and fifth years, estimated glomerular filtration rate (eGFR) values were calculated, and the data were analyzed using a linear mixed model with time as a fixed effect and patient as a random effect. Results: A total of 175 patients (male: 49.1%, mean age: 59 +/- 12.4 years) were included. When comparing the middle and high UHR groups with the low UHR group, it was found that the eGFR values of the middle and high UHR groups were lower. Although no significant difference was found between the middle MHR group and the low MHR group, it was observed that the eGFR values of the high MHR group were significantly lower compared to the low MHR group. Conclusion: Higher UHR and MHR values were associated with greater eGFR decline over 5 years in CKD patients. The UHR appeared to show a more consistent association with CKD progression than MHR, suggesting it may serve as a useful indicator in risk stratification and disease monitoring. These findings warrant confirmation in larger prospective studies.
