PP SUBRAMANİ, SV KHARE, SP CHOUDHARİ, SP PHALLE, SS KUMBHAR, VS KAVADE, AA PRATAVALE, PB CHOUDHARİ
Journal of Research in Pharmacy - 2017;21(3):631-643
Fatty acid biosynthesis is an important process in the microorganism life cycle. β-Ketoacyl-acyl Carrier Protein Synthase III (FABH) catalyzes a critical step in fatty acid biosynthesis via type ii fatty acid biosynthesis. Series of 43 Benzoyl amino benzoic acid derivatives were subjected to 2D and 3D quantitative structure-activity relationships (QSAR) analysis via multiple linear regression and partial least square analysis respectively. Statistically significant four QSAR models were developed with good cross-validated correlation coefficient and external validation values. Developed QSAR model indicated the significance of the lipophilic parameters in an inhibitory potential of benzoyl amino benzoic acid derivatives.
