METİN TURAN, TUGBA KIRKIK, MUSTAFA GUZEL, AYTEN ALTINTAS
Acta Pharmaceutica Sciencia - 2025;63(2):381-395
Breast and pancreatic cancers are among the leading causes of death worldwide. In this study, the anticancer activities of natural-based montmorillonite and modified curcumin are examined in pancreatic and breast cancer. MRC-5, PANC-1, and MDA-MB-231 cell lines are used as healthy fibroblast cell lines (control), pancreatic and breast cancer respectively. 10-1000 μg/mL doses applied to each cell line. As a result, we obtained that montmorillonite has no significant reducing effects on cell viability in the MRC-5 cell line. IC50 values were 1456 μg/mL for MDA-MB-231 and 1166 μg/mL for PANC-1 cells. When modified curcumin therapy doses were applied, IC50 values were 215 μg/mL for MRC-5, 56.45 μg/mL for MDA-MB-231, and 72.34 μg/mL for PANC-1 cells. In conclusion, this study demonstrates that these two natural compounds have antitumoral effects on pancreatic and breast cancer. These compounds may be useful in the development of natural-based treatments for breast and pancreatic cancer.
