MÜRŞİT CEYHUN BİRİNCİ, ALİ KARADENİZ
Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi - 2023;18(1):102-107
Objective: In this study, the effect of alpha-lipoic acid (ALA) administration on the lipid peroxidation, kreatin kinase and lactate levels in mice exposed to swimming exercise was examined. Materials and Methods: In this study 30 adult Swiss albino mice weighing 20-25 g were used. The mice were divided into three groups as control, ALA-50 and ALA-100 each consisting of 10. The mice in control group received intraperitoneal (i.p) isotonic serum throughout 10 days. The ALA-50 and ALA-100 groups were given 50 and 100 mg/kg concentrated ALA, i.p. At the end of the 10th day, the mice were taken into the swimming pools and subjected to swimming test. After the swimming test, the muscles and blood samples of the mice were collected and analyzed biochemically. Results: When the data obtained were compared with the control group, there was an increase at the swimming period, GSH, GSH-Px and SOD values, and a decrease at the levels of CK, LDH and MDA. Conclusion: As a result, the presence of the damage in muscle tissues of the mice performed acute swimming exercise was biochemically detected. We believe that it will be possible to be able to preventing or delaying oxidative damage and muscle fatigue caused by strenuous swimming exercise by the administration of alpha lipoic acid.
