Makbule AKCIN, Ece ONUR, Cevval ULMAN, Yeşim GÜVENÇ DEMİRAĞCI, Elif FIRAT, Aybike Ecmel CINKARA, Fethi AKTAŞ, Muhammed Nurullah YİĞİT, Aleyna KIRMIZI, Veysel Can TAŞKIRAN, Fatma TANELİ
Journal of Turkish Clinical Biochemistry - 2026;24(1):12-14
Luteinizing hormone (LH) levels may occasionally be elevated in individuals without any clinical manifes-tations. One possible explanation for this finding is the presence of macro LH, an immunoglobulin-bound form of LH that forms immune complexes and is cleared slowly from circulation. An eight-year-old boy with no clinical signs of puberty was found to have elevated LH levels for his age. To investigate the possibility of macro LH, serum samples were treated with polyethylene glycol (PEG) to precipitate high-molecular-weight complexes. Following PEG precipitation, a marked decrease in LH concentration was observed, confirming the presence of macro LH. The detection of macro hormones such as macro LH is essential to avoid misdiag-nosis and unnecessary treatments. This case emphasizes the importance of interpreting laboratory findings in the context of the patient's clinical presentation.
