IS MAINTENANCE CHEMOTHERAPY ALWAYS NECESSARY IN GESTATIONAL TROPHOBLASTIC NEOPLASIA? A RETROSPECTIVE COHORT ANALYSIS

EMRE HAFIZOĞLU, MURAT BARDAKÇI, EFNAN ALGIN, ÖZNUR BAL, DOĞAN UNCU

The European Research Journal - 2025;11(5):1001-1007

Department of Medical Oncology, Afyonkarahisar State Hospital, Afyonkarahisar, Türkiye

 

Objectives: Gestational trophoblastic neoplasia (GTN) is a rare but highly curable group of gestational tumors. Current risk stratification relies on the International Federation of Gynecology and Obstetrics (FIGO) staging and WHO scoring systems, yet both have shown limited accuracy in predicting relapse or chemoresistance. The necessity of routine maintenance chemotherapy following remission - particularly in low-risk patients - remains controversial.