Enes Durak, Aslı Aksoy Gündoğdu
Archives of Epilepsy - 2025;31(4):155-158
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, potentially life-threatening hypersensitivity reaction characterized by fever, skin rash, eosinophilia, and multiple organ involvement. Here we report an 18-year-old female patient with epilepsy who developed fever, widespread erythematous rash, facial edema, and elevated liver enzymes six weeks after the initiation of lamotrigine therapy. With a the registry of severe cutaneous adverse reaction score >=6, a diagnosis of DRESS syndrome was established. Lamotrigine was discontinued, and oral corticosteroid therapy was initiated. Clinical improvement was observed by the third day, liver function tests normalized within 10 days, and cutaneous lesions gradually regressed. In patients receiving lamotrigine, the occurrence of fever and cutaneous rash should raise suspicion for DRESS syndrome in the differential diagnosis. Early diagnosis and treatment are critical for preventing systemic complications.
