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LICHENOID DRUG ERUPTION DUE TO PIRFENIDONE IN A PATIENT WITH IDIOPATHIC PULMONARY FIBROSIS

MEHMET SEMİH CELİK, CANDAN CELİK, NAGEHAN CEPİK, MEHMET SELCUK OZERCAN

Journal of Clinical Trials and Experimental Investigations - 2024;3(3):60-64

Firat University Hospital, Department of Dermatology, Elazig, Turkey

 

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause characterized by relentless scarring in the lung parenchyma, leading to decreased quality of life and early mortality. Pirfenidone and nintedanib have been approved for the treatment of IPF based on their ability to slow functional decline and disease progression. Lichenoid drug eruption (LDE) refers to a drug-induced eruption resembling lichen planus, typically presenting as purple, symmetrical, eczematous plaques. While skin reactions due to pirfenidone have been reported in numerous cases, pirfenidone-induced LDE is rarely observed. In this case, we present a rare instance of pirfenidone-induced LDE.