AHYOUNG KİM, NAZİHEH ASSARZADEGAN, ROBERT A ANDERS, KİYOKO OSHİMA, SHRUTİ CHATURVEDİ, SHARON WEEKS, RUHAİL KOHLİ, SOPHİE LANZKRON, AHMET GURAKAR, JACQUELİNE GARONZİK WANG, PO HUNG CHEN
Experimental and Clinical Transplantation - 2022;20(4):429-432
Although liver transplant is a life-saving measure for individuals with end-stage liver disease, the perioperative management may be challenging in individuals with concomitant sickle cell disease. We report a case of a 50-year-old man with sickle cell disease genotype SC (HbSC) and cirrhosis secondary to autoimmune hepatitis who underwent liver transplant. His postoperative course included upper extremity deep vein thrombosis, pulmonary embolus, stroke via a patent foramen ovale after a line removal, and posterior reversible encephalopathy syndrome. Fortunately, he is alive with a functioning graft at 10 months after liver transplant. This case highlights the feasibility of liver transplant in sickle cell disease given the support of meticulous multidisciplinary care and the unique aspects of autoimmune hepatitis and sickle cell disease for liver transplant consideration.
