BÜLENT ÖZÇELİK, MUSTAFA BAŞBUĞ, MÜSLÜM SARIKAYA, İBRAHİM S SERİN, MEHMET TAYYAR, MUSTAFA KENDİRCİ
Gynecology Obstetrics & Reproductive Medicine - 2004;10(3):167-171
Objective: To examine the effectiveness of low dose vitamin E (vit E) in the prevention of preeclampsia in women without predisposing historical risk factors. Study Design: Two-hundred-sixty low-risk pregnant women between 13 and 20 gestational weeks were enrolled to the study and randomly divided into two groups, a vit E and control group. In the vit E group, 100 IU/day vit E was used. Blood samples for the first measurement were taken at the enrollment. For the second measurement 32 healthy pregnant women were randomly selected between 30 and 38 weeks in each group and blood samples were collected. Samples from preeclamptic patients were also collected at the diagnosis of preeclampsia. Results: There was no statistical difference between the vit E and control groups with regard to incidence of preeclampsia and the first measurement of maternal vit E levels. When we compared first and second measurement maternal vit E levels of preeclamptic women within groups, no difference was found in vit E group (1.02±0.06, 0.98±0.08 respectively; p>0.05), however, a statistical difference was determined in control group (1.01±0.07, 0.95±0.06; p<0.05). In the preeclamptic patients, the first and second measurement vit E levels were not different between groups. Second measurement vit E levels (1.10±0.06) of healthy subjects in vit E group were statistically different from first measurements of themselves (1.01±0.09) (p<0.05) and second measurements of the healthy subjects (1.03±0.09) (p<0.05) in control group at the same time. Conclusion: Low-dose vit E supplementation is not effective in the prevention of preeclampsia in women at low-risk according to historical risk factors.
