MALARIA CAUSING CARDIOMYOPATHY AND THROMBOTIC MICROANGIOPATHY: A RARE ASSOCIATION

DEEPAK JAİN, NİTYA NAND, PREETİ VERMA, DİSHA SAXENA, PROMİL JAİN

Journal of Clinical Practice and Research - 2018;40(4):237-239

Sharma University Faculty of Health Sciences, Haryana, India

 

We report a case of dual comorbidities of thrombotic microangiopathy (TMA) and cardiomyopathy associated with Plasmodium vivax malaria. A 20-year-old girl presented with worsening anemia, persistent thrombocytopenia, acute kidney injury, and sinus bradycardia with ST–T changes. Hemolytic uremic syndrome was diagnosed based on schistocytes on peripheral blood film, increased serum lactate dehydrogenase, and elevated reticulocyte production index. Kidney biopsy revealed TMA. Echocardiography initially revealed dilated cardiomyopathy with low ejection fraction that improved to normal on follow-up. The patient was kept on maintenance hemodialysis during acute illness, and later she became dialysis dependent. She has now been advised for renal transplantation.