Barış Yasin VARLIK, Özlem KANBUROĞLU MELETLİ, Özge ÜÇÜNCÜ, Şafak ERSÖZ
Endocrinology Research and Practice - 2026;30(2):134-136
Adrenal ganglioneuromas are rare, well-differentiated tumors of sympathetic origin derived from neural crest cells. This case presents a non-functional but radiologically suspicious right adrenal mass, which was removed laparoscopically and histopathologically diagnosed as a ganglioneuroma. A 25-year-old male presented with dysuria. Abdominal magnetic resonance imaging revealed a 55 x 34 mm right adrenal mass. Ambulatory blood pressure monitoring showed no hypertension. Hormonal evaluation excluded pheochromocytoma, hyperaldosteronism, and hypercortisolism. Dehydroepiandrosterone sulfate was within the normal range. On the adrenal wash-out protocol computed tomography, the relative wash-out was -16.3% and absolute wash-out -87.5%, suggesting a non-adenomatous lesion. Laparoscopic right adrenalectomy was performed under the pre-diagnosis of a non-functional, non-adenomatous adrenal mass. Histopathological examination revealed a 6.5 x 4.7 cm ganglioneuroma. Density and wash-out parameters are insufficient to rule out malignancy in non-functional adrenal lesions. Surgical resection is appropriate for lesions >=4 cm, with attenuation >20 Hounsfield Unit and atypical wash-out features. Following laparoscopic adrenalectomy for non-adrenocortical benign neoplasms, the prognosis is excellent, and recurrence is exceedingly rare.
