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MANAGEMENT OF COVID-19 IN LIVER TRANSPLANT RECIPIENTS WITH IMMUNOSUPPRESSANT THERAPY: EXPERIENCES OF AN IRANIAN TRANSPLANT REGISTRY

ZAHRA SHEİKHALİPOUR, TOURAJ ASVADİ KERMANİ, FARZAD KAKAEİ, AZİZEH FARSHBAF KHALİLİ, LEİLA VAHEDİ

Experimental and Clinical Transplantation - 2022;20(3):285-292

From the Medical and Surgical Department, the Department of Surgery, Tabriz University of Medical Sciences, Tabriz, Iran

 

Objectives: With the declaration of the COVID-19 pandemic and the increased COVID-19 risk shown in transplant recipients, the prevalence, clinical course, and outcomes of COVID-19 infections among liver transplant recipients were assessed. Materials and Methods: A questionnaire was designed and used to survey medical services for liver transplant recipients seen at our center in terms of COVID-19 infection. Results: Twenty-five patients infected with COVID-19 were identified from 265 liver transplant recipients. Most patients were male and had COVID-19 despite quarantine at home. All patients received modified immunosuppressive drugs during infection with COVID-19 with minor changes in routine immunosup - pressive therapy. Among the identified patients, 21 recovered and 4 patients died. One of the dead patients, in addition to having a liver transplant, had brain cancer with metastasis to the lungs. Conclusions: In liver transplant recipients infected with COVID-19, immunosuppressive drugs seemed to cause only mild to moderate illnesses or even helped them recover from the disease. However, more evidence is needed to prove this hypothesis. It is also recommended that transplant recipients should be warned about personal hygiene and be monitored closely by organ transplant centers.