Adelyn D'Souza, Saloni Hiteshkumar Jariwala, Yajnesh C Shetty, Caren D'souza, Vijith Shetty
Gulhane Medical Journal - 2025;67(4):285-288
Metastatic malignant melanoma, which presents as obstructive jaundice due to common bile duct (CBD) involvement, is exceedingly rare. We present a case of a 36-year-old woman with metastatic malignant melanoma involving multiple organs including the lungs, pancreas, gallbladder, chest wall, and cervix, complicated by obstructive jaundice of unknown primary origin. Diagnostic evaluation revealed widespread metastases confirmed by histopathology and immunohistochemistry, positive for human melanoma black 45 and S-100. Treatment included placement of a self-expanding metallic stent in the CBD and initiation of pembrolizumab immunotherapy. This case highlights the diagnostic challenges and therapeutic considerations in managing metastatic melanoma with unusual biliary tract involvement.
