Hossein NAJAFPOUR, Azam RIAZAT
Journal of Multiple Sclerosis Research - 2026;6(1):26-30
Functional improvement in late-onset secondary progressive multiple sclerosis is uncommon, particularly in elderly patients with a long disease duration. We report the case of a 75-year-old man with symptom onset after the age of 50 and more than 20 years of progressive multiple sclerosis who experienced sustained, multidomain functional improvement following a short, non-invasive, non-pharmacological, device-free Somatic-neuropsychological adaptive programming system program delivered over approximately 60 days. The patient had not received disease-modifying therapy or physiotherapy for several years prior to the intervention. Global disability, assessed using the composite disability and functional status Scale, decreased from 29/50 to 3/50, accompanied by improvements across physical, functional, and psychological domains. Clinical improvements remained stable at 3-, 9-, and 12-month follow-up, with no adverse events reported. These findings should be interpreted as hypothesis-generating clinical observations rather than as evidence of treatment efficacy.
