Hossein NAJAFPOUR, Azam RIAZAT
Journal of Multiple Sclerosis Research - 2026;6(1):22-25
Rapid, multidomain functional improvement is uncommon in primary progressive multiple sclerosis (PPMS). We report the case of a 44-year-old man with long-standing PPMS who completed a 15-session, device-free somatic-neuropsychological adaptive programming system program over 90-days. Global disability, assessed using the composite disability and functional status scale, improved from 20/50 to 7/50. Lower-limb strength increased (Medical Research Council scale: left, 0 ->1; right, 2 ->4). The Babinski sign normalized on the right and attenuated on the left. Multiple physical and psychological symptoms improved across 0-10 severity scales. One routine rituximab infusion occurred during the intervention period. Clinical gains persisted at 3 and 9 months without relapse or regression, despite exposure to significant psychosocial stressors. No adverse events were observed. These findings warrant further investigation in controlled, blinded studies.
