ABDULLAH Q KHUDHUR, AHMED HAMZA AL SHAMMARI, ALAA A ABDULRASOOL
Acta Pharmaceutica Sciencia - 2024;62(3):705-711
This study was aimed at preparing and assessing the Naproxen-phospholipid complex (NP-PL) as a vesicular drug delivery system prepared by solvent evaporation method. Attenuated total reflection (ATR) spectroscopy was used to confirm the interaction, while a dissolution study was used to compare the dissolution profiles for the NP drug, the NP-PL complex, and the marketed NP suspension. Results revealed that the ATR spectra showed some changes that confirm the complexation between the PL and NP, and better dissolution behavior was shown by the NP-PL pharmacosomes compared to the NP suspension and the pure NP, which indicates that the potential of making a phospholipid complex with an improved dissolution profile of Naproxen was investigated and a successful NP-PL pharmacosomes was prepared. ATR data confirmed NP-PL complex formation. In-vitro dissolution profiles of NP pharmacosomal dispersion showed improvement over marketed NP and pure NP.
