JAYMİN M PATEL, KAUSHİKA PATEL, SHREERAJ SHAH
Acta Pharmaceutica Sciencia - 2024;62(2):333-354
The study aimed to create an effective colon-targeted budesonide delivery system using natural polymers. Various natural gums were assessed for their ability to develop a microbial degradation-based colon-targeted drug delivery system. The sensitivity of polymers to colonic enzymes was tested by evaluating viscosity changes in the presence of a prebiotic culture medium simulating rat cecal content. Tamarind gum and Karaya gum exhibited superior viscometric profiles. Compression coating with these gums, followed by an Eudragit S 100 coat, was employed for successful colon delivery. A 32-factorial design optimized the system, using variables like polymer to ethyl cellulose (EC) ratio and Eudragit S 100 weight gain. The design-space stipulated less than 10% drug release in 2 hours (h), less than 15% in 5 h, and over 50% in 7 h for colon targeting. The Tamarind gum batch (TM 9) released 8.91% at 5 h and 50.23% at 7 h, achieving optimal drug delivery to the colon.
