Mariam Al-Abdallah, Nabeel Al-Sadi, Hadeel Tayeh, Nebras Althaga fi, Rawah Eshky, Najla Dar-Odeh
European Journal of General Dentistry - 2026;15(1):124-136
A dental anomaly is any deviation from normal tooth development, affecting the number, size, form, position, or structure of one or more teeth. Examining affected family members can enhance our understanding of the genetic factors involved in both normal and abnormal dental development. Hypodontia is a common dental anomaly characterized by the congenital absence of one or more teeth. It may exhibit a familial pattern associated with certain dental anomalies in siblings. The two main treatment modalities for hypodontia are space opening for prosthetic replacement of the missing tooth or space closure, which underscores the need for an interdisciplinary approach of management. This case series aims to present the clinical dental features and treatment modalities of 10 siblings from 5 families who exhibited hypodontia and other nonsyndromic dental anomalies with malocclusion. A thorough literature review on familial and genetic basis of hypodontia and associated dental anomalies in siblings is also presented.
