RAMATU IDRİS, MARYAM AKOR-DEWU, ABDULRAHMAN ABDULSAMAD, FATİMA CİROMA, SHEHU-TİJANİ SHİTTU
Acta Pharmaceutica Sciencia - 2020;58(3):321-334
This study investigates the effect of omega 3 and Vitamin A on joint inflammation in Wistar rats. Joint inflammation was induced by carrageenan and the animals were treated with omega 3, Vitamin A or a combination of both for 10 days. Changes in Knee diameter (KnD), Tumor Necrosis Factor-α (TNF-α) level and C-Reactive protein (CRP) level were assessed to determine treatment efficacy. Carrageenan caused significant increase in KnD, TNF-α and CRP compared to the control. Treatments with Omega 3 alone or in combination with Vitamin A significantly reduced the elevated KnD, TNF-α and CRP. Vitamin A alone produced similar effect on KnD and TNF-α but had no effect on CRP. It is thus concluded that though both treatments decreased knee diameter at the 10th week, Omega 3 alone and in combination with Vitamin A showed a better outcome with a higher decrease in TNF-α and CRP than Vitamin A alone.
