DERYA ÖZSAVCI
Advances in Molecular Medicine - 2007;3(2):57-61
Free radicals and other reactive species are produced during aerobic metabolism in the body. ROS occurring in vivo can cause oxidative damage of aminoacids, lipids, proteins and DNA. Excess ROS may induce the formation of oxidative DNA damage, DNA strand breaks, base modifications and chromosomal aberrations. For repair of oxidative DNA damage, human cells are supported by five DNA repair systems. These are: direct reversal, mismatch repair, double-strand break repair, base excision repair (BER) and nucleotide excision repair (NER). DNA repair gene polymorphism accounts for individual variations in DNA repair capacity, thus the genetic background of subjects are the most important implications for prospective disease risks.
