ERHAN AYSAN, ULKAN KİLİC, OZLEM GOK, BURCUGUL ALTUG, CİLEM ERCAN, CEMİLE KESGİN TOKA, UFUK OGUZ IDİZ, MAHMUT MUSLUMANOGLU
Experimental and Clinical Transplantation - 2016;14(2):238-241
Objectives: To develop a new parathyroid allotransplant method for the treatment of permanent hypoparathyroidism. Materials and Methods: Parathyroid cells 50 × 106 derived from a parathyroid hyperplasia patient were transferred to a 61-year-old patient who had thyroidectomy 17 years earlier, allowing to papillary thyroid cancer; he was admitted to our outpatient clinic with symptomatic chronic hypocalcemia. Cell isolation, cryopreservation, and culturing were conducted according to a new protocol. Results: During a follow-up of 5 months, the patient had no complications that could indicate rejection, and clinical symptoms completely resolved without requiring any drug supplementation. Conclusions: Here, we report a new method, enabling fast and cost-effective parathyroid allotransplant with maintained tissue viability sufficient to treat persistent hypocalcemia.
