MUSTAFA CAN GÜLER, AYHAN TANYELİ, ERSEN ERASLAN, MEHMET RAMAZAN BOZHÜYÜK, FAZİLE NUR EKİNCİ AKDEMİR, ERDEM TOKTAY, NEZAHAT KURT, ESRA ÇAPANOĞLU GÜVEN, GÜLAY ÖZKAN
Southern Clinics of Istanbul Eurasia - 2021;32(1):1-7
INTRODUCTION: The worldwide incidence of a gastric ulcer is high, most often as a result of use of nonsteroidal anti-inflammatory drugs, excessive alcohol consumption, or Helicobacter pylori infection. An ethanol-based gastric ulcer model in rats was used to examine the effect of persimmon (Diospyros kaki L.) extract as a potential form of treatment. METHODS: Two dosages of persimmon extract were applied in a gastric ulcer model created with 5 mL/kg ethanol in Wistar albino rats. Histopathological and biochemical methods were used to assess any gastroprotective effects. Results: Persimmon extract significantly decreased the level of the cytokines interleukin (IL)-10, IL-6, tumor necrosis factor alpha (TNF-α) and IL-1 beta. Caspase-3 and nuclear factor kappa B expression was also significantly reduced. DISCUSSION AND CONCLUSION: Persimmon fruit extract demonstrated a gastroprotective effect in an ethanol-based gastric ulcer model in rats.
