PREDICTING HEPATOCELLULAR CARCINOMA DEVELOPMENT IN ADVANCED FIBROSIS OR CIRRHOSIS DUE TO CHRONIC HEPATITIS B: THE ROLE OF GLYPICAN-3, HEAT SHOCK PROTEIN 70, CD34, AND GLUTAMINE SYNTHETASE

YUSUF OZTURK, TUGRUL PURNAK, HALİS SİMSEK, CENK SOKMENSUER

Hepatology Forum - 2025;6(3):99-104

Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkiye

 

Background and Aim: Numerous studies have demonstrated associations between hepatocellular carcinoma (HCC)-related features and markers such as glypican-3 (GPC3), heat shock protein 70 (HSP70), CD34, and glutamine synthetase (GS). In this study, we aimed to quantify these markers in the tissues of patients with cirrhosis or advanced fibrosis due to chronic hepatitis B (CHB).