MUHAMMED MUSTAFA ATCİ, RUHPER CEKİN
Eurasian Journal of Medical Investigation - 2021;5(3):388-393
Objectives: To investigate the relationship between the level of vitamin D with pathological response rates to neoad juvant chemotherapy in breast cancer patients. Methods: The pathological responses of patients treated with neoadjuvant chemotherapy for locally advanced breast cancer regarding Miller-Payne grading system were noted as ?90% and >90% response. Vitamin D deficiency was de fined as <20 ng/mL. Results: Eighty-nine patients with a mean age of 49.7±12.1 years old were included. Forty-two (47.2%) patients were postmenopausal. Vitamin D deficiency was present in 38 (42.7%) patients. Forty-eight (53.9%) and 41 (46.1%) patients had a pathological response rate of ?90 and >90 to neoadjuvant chemotherapy, respectively. In univariate analysis, tumor size, menopause status, and histologic grade were found to be statistically significant for pathological response. In multivariate analysis, progesteron receptor positivity, premenopause, and higher tumor diameter were associated with decreasing pathologic response. The level of vitamin D was not statistically significant on pathological response to neoadjuvant chemotherapy. Conclusion: The level of vitamin D level was not associated with pathologic response rates to neoadjuvant chemother apy in Turkish population. This may be explained with vitamin D receptor polymorphism in different ethnicities which should be evaluated in future studies in terms of pathologic response to neoadjuvant chemotherapy.
