APOSTOLOS P ATHANASIADIS, KONSTANTİNOS N CHATZIGEORGIOU, CHRİSTİNA TZANNATOU, THEMİSTOKLİS MIKOS, GRİGORİS GRIMBIZIS, JOHN N BONTIS
Gynecology Obstetrics & Reproductive Medicine - 2005;11(2):124-126
Holoprosencephaly is a heterogeneous entity characterized by defects of the mid forebrain and face, due to the impaired midline cleavage of the embryonic forebrain and is one of the most common developmental disorders of the brain. Prenatal diagnosis of cerebral abnormalities with the conventional two-dimensional (2D) ultrasound is well documented. Accompanying anomalies such as facial deformities and holoprosencephaly, have recently been described with the use of three-dimensional (3D-4D) ultrasound. The application of this novel diagnostic modality seems to increase accuracy and sensitivity of prenatal ultrasound. We review the international literature apropos of a representative case documented both with 2D and 3D ultrasound.
