TUGBA AKİN TELLİ, NİSANUR SARİYAR, OZKAN ALAN, NAZİM CAN DEMİRCAN, SELVER ISİK, RUKİYE ARİKAN, TUGBA BASOGLU, ALPER YASAR, ABDUSSAMET CELEBİ, OMER SOFULU, BULENT EROL, HUSEYİN KEMAL TURKOZ, ZERRİN OZGEN, OZLEM ERCELEP, FAYSAL DANE, PERRAN FULDEN YUMUK
Eurasian Journal of Medical Investigation - 2021;5(2):256-262
Objectives: Prognostic nutritional index (PNI) is an inflammation-based score which was found to be predictive of survival for different types of cancer. Aim of present study is to investigate the association between PNI and survival outcomes in patients with soft tissue sarcoma (STS) operated with curative intent. Methods: We retrospectively collected data of 86 patients with localized STS. Preoperative PNI was calculated with the following formula:10×serum albumin (g/dL)+0.005×total lymphocyte count (per mm3 ). Patients were classified into 2 groups based on median PNI value. Results: Median age was 52.5 (18-86) years. There were 49 male and 37 female patients. Most common histology was liposarcoma (26.7%). Our cohort mainly included stage 3 (69.8%) and grade 3 (66.3%) tumors. Radiotherapy and che motherapy were applied to 69.8% and 48.8% of patients, respectively. Median value of PNI was 48.2 (25.5-68.0). Median follow-up duration was 25 months (3-120). Median overall survival (OS) was 84.6 months (95% CI, 72.0-97.3). Median OS of patients with high PNI (?48.2) was significantly longer than patients with low PNI (<48.2), being 99.6 months(95% CI, 83.6-115.6) and 64.5 months(95% CI, 50.3-78.7), respectively(p=0.02). Multivariate analysis determined PNI as an independent prognostic indicator for OS [HR: 2.96, (95% CI 1.117.87), p=0.02] along with age. Conclusion: Our findings suggest that PNI predicts OS independently in patients with STS. Therefore, PNI is a valuable prognostic tool in preoperative setting.
